What is a major risk associated with Romosozumab?

What is a major risk associated with Romosozumab?

• A. Weight gain and hair loss
• B. Osteonecrosis of the jaw and cardiovascular events
• C. Improved dental health
• D. No known risks

Answer: (B)

Romosozumab carries safety signals that include cardiovascular events and osteonecrosis of the jaw. The drug is a sclerostin inhibitor that strongly boosts bone formation, but this effect has been linked in studies to an increased risk of major adverse cardiovascular events such as heart attack and stroke, leading to warnings about cardiovascular risk. There is also a recognized risk of osteonecrosis of the jaw, particularly around dental procedures or in patients with dental disease or poor calcium/phosphate balance. Because the question highlights these two specific major risks, the option listing osteonecrosis of the jaw and cardiovascular events best captures the known safety concerns with romosozumab. The other choices don’t reflect the real safety profile—weight gain and hair loss aren’t typical risks, improved dental health isn’t a risk, and saying there are no known risks is incorrect.

Romosozumab carries safety signals that include cardiovascular events and osteonecrosis of the jaw. The drug is a sclerostin inhibitor that strongly boosts bone formation, but this effect has been linked in studies to an increased risk of major adverse cardiovascular events such as heart attack and stroke, leading to warnings about cardiovascular risk. There is also a recognized risk of osteonecrosis of the jaw, particularly around dental procedures or in patients with dental disease or poor calcium/phosphate balance. Because the question highlights these two specific major risks, the option listing osteonecrosis of the jaw and cardiovascular events best captures the known safety concerns with romosozumab. The other choices don’t reflect the real safety profile—weight gain and hair loss aren’t typical risks, improved dental health isn’t a risk, and saying there are no known risks is incorrect.